Dextromethorphan Hydrobromide and Chlorpheniramine Maleate Syrup


Children often cough when they have a cold because of mucus trickling down the back of the throat. Although it’s upsetting to hear your child cough, coughing helps clear away phlegm from the chest or mucus from the back of the throat. Children can cough several times a day or have coughing episodes lasting up to a couple of weeks if they have viral infections. However, coughing that lasts more than two to three weeks should prompt a visit to your paediatrician. The majority of children have brief repeated periods of coughing due to viral upper respiratory tract infections, such as the common cold.

A dry cough means it’s tickly and doesn’t produce any phlegm (thick mucus). Because there is not mucus blocking the lungs or airways hence nothing comes out when you cough. This lack of mucus makes it an unproductive cough. Cough suppressants (antitussives) quiet your cough by blocking your cough reflex. This helps in dry coughs that are painful or that keep you up at night. First generation antihistamines like chlorpheniramine are often used alone or in combination in the
management of nonspecific cough.

Cofboj DX Syrup is a combination of Dextromethorphan and Chlorpheniramine Maleate is used for effective treatment of dry cough due to allergy. This product is intended to be used for relief of cough and upper respiratory symptoms, including nasal congestion associated with allergy or the common cold.

Mode of action 

Dextromethorphan suppresses the cough reflex by a direct action on the cough center in the medulla of the brain. Dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center.

Chlorpheniramine competes with histamine for the normal H 1 -receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract.

Directions for use 

  • Children above 6 years 2.5 ml (1/2 teaspoonful) 4 times daily.
  • Children between 2-6 years 1.25 ml (1/4 teaspoonful) 4 times daily.


  • Dry Allergic Cough
  • Whooping Cough

Side effects 

The most common side effect is drowsiness. This drowsiness can be helpful if other symptoms are particularly troublesome at night.

The following side effects may occur. If you get any of the following side effects, stop taking this medicine and see your doctor.

  • Loss of appetite, indigestion, feeling or being sick, diarrhoea, tummy pain or dry mouth.
  • Low blood pressure or changes in heart rhythm.
  • Chest tightness or thickening of phlegm.
  • Confusion, excitability, irritability, low mood or nightmares.
  • Children may become excited.
  • Skin rash.
  • Feeling sick, being sick, headache.
  • Fast or irregular heartbeat, high blood pressure.

Storage and safety information 

  • Keep this medicine out of the sight and reach of children.
  • Pregnancy: Not established study for this combination hence this combination should be administered with caution in pregnancy.
  • Lactation: Since many drugs are excreted in human milk and because of the potential for serious side effects in nursing infants.